Hemorrhage promotes inflammation and myocardial damage following acute myocardial infarction: insights from a novel preclinical model and cardiovascular magnetic resonance

• DOI: 10.1186/s12968-017-0361-7
• Publication Date: 2017-07-04T07:16:07Z
• Authors: Nilesh R. Ghugre; Mihaela Pop; Reuben Thomas; Susan Newbigging; Xiuling Qi; Jennifer Barry; Bradley H. Strauss; Graham A. Wright
• Keywords: Coronary occlusion

Myocardial hemorrhage is a frequent complication following reperfusion in acute myocardial infarction and predictive of adverse outcomes. However, it remains unsettled whether simply marker severe initial ischemic insult or directly contributes to downstream damage. Our objective was evaluate the contribution towards inflammation, microvascular obstruction infarct size novel porcine model hemorrhagic using cardiovascular magnetic resonance (CMR).