Regional assessment of carotid artery pulse wave velocity using compressed sensing accelerated high temporal resolution 2D CINE phase contrast cardiovascular magnetic resonance

• DOI: 10.1186/s12968-018-0499-y
• Publication Date: 2018-12-17T10:32:57Z
• Authors: Eva S. Peper; Gustav J. Strijkers; Katja Gazzola; Wouter V. Potters; Abdallah G. Motaal; Ilse K. Luirink; Barbara A. Hutten; Albert Wiegman; Pim van Ooij; Bert-Jan H. van d...; Aart J. Nederveen; Bram F. Coolen
• Keywords: Temporal resolution; Angiology; Magnetic resonance angiography

Cardiovascular magnetic resonance (CMR) allows for non-invasive assessment of arterial stiffness by means measuring pulse wave velocity (PWV). PWV can be calculated from the time shift between two time-resolved flow curves acquired at locations within an segment. These derived two-dimensional CINE phase contrast CMR (2D PC CMR). While CMR-derived measurements have proven to accurate aorta, this is more challenging smaller arteries such as carotids due need both high spatial and temporal resolution. In work, we present a novel method that combines retrospectively gated 2D CMR, binning data compressed sensing (CS) reconstruction accomplish resolution 4 ms. This enables in regional carotid artery segments. Retrospectively was binned into cardiac frames ms length, resulting incoherently undersampled ky-t-space with mean undersampling factor 5. The images were reconstructed non-linear CS using total variation over sparsifying transform. values foot-to-foot cross-correlation methods. Our validated against ultrasound phantom setup representing artery. Additionally, groups 23 young (30 ± 3 years, 12 [52%] women) 10 elderly (62 5 [50%] healthy subjects compared Wilcoxon rank-sum test. proposed produced very similar those measured 1 Reliable estimation proved possible transit times down 7.5 Furthermore, significant differences found (4.7 1.0 m/s 7.9 2.4 m/s, respectively; p < 0.001) accordance literature. spatiotemporal calculations. We foresee technique will valuable protocols investigating early development atherosclerosis.