Effect of different doses of aspirin on the prognosis of Kawasaki disease

• DOI: 10.1186/s12969-020-00432-x
• Publication Date: 2020-06-11T18:03:52Z
• Authors: Jinxin Wang; Huiqiao Chen; Hongying Shi; Xuting Zhang; Yiping Shao; Biyao Hang; Zhipeng Xu; Xing Rong; Maoping Chu; Huixian Qiu
• Keywords: Coronary artery aneurysm

Abstract Background Kawasaki disease (KD) is the leading cause of acquired heart in children, and steadily increasing prevalence East Asia. KD often complicated by coronary artery damage, including dilatation and/or aneurysms. Aspirin used with intravenous immunoglobulin (IVIG) to prevent abnormalities KD. However, role optimal dose aspirin remain controversial. Identifying acute phase will facilitate development a more appropriate treatment strategy improving outcome Methods A total 2369 patients were retrospectively analyzed divided into three groups according dose: 510 group 1 (20–29 mg/kg/day), 1487 2 (30–39 372 3 (40–50 mg/kg/day). The differences laboratory data, rate IVIG resistance damage compared among groups. Results There was no difference incidence aneurysms (CAAs) (2 weeks illness: 2.94% vs. 1.90% 3.36%; 3–4 1.94% 2.32% 2.65%). risk for developing CAA not reduced at illness onset (adjusted OR = 1.05, 95% confidence interval: 0.34–3.18; aOR 1.81, CI: 0.42–7.83). Furthermore, (aOR 2.63, 0.61–11.28; 0.52, 0.03–9.54). significant Platelet levels after significantly lower than those (522.29 × 10 9 /L, 544.69 557.77 p 0.013). C reactive protein 30-40 mg/kg*day slightly higher other two (7.76, 8.00, 7.01 mg/L, 0.028). Conclusions 20–29 mg/kg/day increase 30–50 mg/kg/day. This low may have potential effect on liver function.