Capsaicin-enriched diet ameliorates autoimmune neuritis in rats

• DOI: 10.1186/s12974-018-1165-x
• Publication Date: 2018-04-24T09:48:38Z
• Authors: Jeremias Motte; Björn Ambrosius; Thomas Grüter; Hussein Bachir; Melissa Sgodzai; Xiomara Pedreiturria; Kalliopi Pitarokoili; Ralf Gold
• Keywords: Capsaicin; Neuritis

Autoimmune neuropathies are common PNS disorders and effective treatment is challenging. Environmental influence dietary components known to affect the course of autoimmune diseases. Capsaicin as pungent component chili-peppers in human nutrition. An capsaicin on diseases has been postulated. We tested animal model experimental neuritis (EAN) Lewis rat. Rats were immunized with P2-peptide treated different preventive settings. Electrophysiological, histological, molecular biological analyses sciatic nerve performed analyze T-cell macrophage cell count, TRPV1, cytokine expression. Moreover, FACS including intestinal immune system executed. observed an immunomodulatory effect early diet-concept, where a physiological dosage oral was given 10 days before immunization EAN. A reduced inflammation significant detectable clinically, electrophysiologically (CMAPs control group p < 0.01; increase conduction blocks 0.05), histologically (significant reduction T-cells, macrophages demyelination), at level. In contrast, this therapeutic missing from day onwards. As possible underlying mechanism, we able show changes expression receptor small intestine, well altered populations intestine. This first report about nutrient, capsaicin, for neuropathies.