Circulating levels of IL-1 family cytokines and receptors in Alzheimer’s disease: new markers of disease progression?

• DOI: 10.1186/s12974-018-1376-1
• Publication Date: 2018-12-12T13:08:15Z
• Authors: Paola Italiani; Ilaria Puxeddu; Sabrina Napoletano; Emanuele Scala; Daniela Melillo; Simone Manocchio; Antonella Angiolillo; Paola Migliorini; Diana Boraschi; Emilia Vitale; Alfonso Di Costanzo
• Keywords: Male; 0301 basic medicine; IL-1 family; 03 medical and health sciences; Alzheimer Disease; Receptors; Humans; Receptors, Cytokine; RC346-429; Aged; Inflammation; Aged, 80 and over; Subjective memory complaints; Research; Mild cognitive impairment; Alzheimer's disease; Middle Aged; 3. Good health; Alzheimer’s disease; Cytokines; IL-1 family; Inflammation; Mild cognitive impairment; Receptors; Subjective memory complaints; Cytokines; Female; Neurology. Diseases of the nervous system; Cognition Disorders; Alzheimer’s disease; Signal Transduction

Although the mechanisms underlying AD neurodegeneration are not fully understood, it is now recognised that inflammation could play a crucial role in initiation and progression of neurodegeneration. A neuro-inflammatory network, based on anomalous activation microglial cells, includes production number inflammatory cytokines both locally systemically. These may serve as diagnostic markers or therapeutic targets for We have measured levels inflammation-related receptors IL-1 family serum subjects with AD, compared to mild cognitive impairment (MCI), subjective memory complaints (SMC), normal healthy (NHS). Using custom-made multiplex ELISA array, we examined ten factors family, IL-1α, IL-1β, IL-18, IL-33, natural inhibitors IL-1Ra IL-18BP, soluble sIL-1R1, sIL-1R2, sIL-1R3, sIL-1R4. The IL-1α their antagonist IL-1Ra, receptor sIL-1R1 were increased AD. decoy sIL-1R2 was only MCI. IL-33 its sIL-1R4 also significantly higher form accessory complexes, SMC even more Total IL-18 unchanged, whereas inhibitor IL-18BP reduced MCI SMC, highly free characterised by significant alteration circulating family. elevation agreement findings other diseases can be considered marker ongoing inflammation. Increased sIL-1R4, distinguished from diseases. Importantly, negatively correlated impairment. present characteristic disappears making them additional interesting evaluating