Gut microbiome and stages of diabetes in middle-aged adults: CARDIA microbiome study

• DOI: 10.1186/s12986-022-00721-0
• Publication Date: 2023-01-05T16:10:03Z
• Authors: Yi-Han Hu; Katie Meyer; Anju Lulla; Cora E. Lewis; Mercedes R. Carne...; Pamela J. Schreiner; Stephen Sidney; James M. Shikany; Osorio Meirelles; Lenore J. Launer
• Keywords: Interquartile range

Abstract Background Animal and human studies suggest the gut microbiome is linked to diabetes but additional data are needed on associations of specific characteristics. The aim this study was examine composition insulin resistance [Homeostatic Model Assessment Insulin Resistance (HOMA-IR)], duration diabetes, 4 stages [normoglycemia, pre-diabetes, with (+) without (−) medication for diabetes]. Methods Data from a sub-sample (n = 605) Black White participants 30-year follow-up exam prospectively followed community-based Coronary Artery Risk Development in Young Adults cohort (2015–2016; aged 48–60 years). Stool samples were collected sequenced using 16S ribosomal RNA method. Microbial measures included: α diversity (within-person), β (between-person), taxonomies. All analyses adjusted demographic, clinical, lifestyle factors, use relevant medications (full adjustment). Multivariate linear regression models used assess association characteristics genera abundance, while analyzed permutational multivariate analysis variance. Statistical significance set p -value < 0.05 q-value 0.1 abundance analyses. Results There 16.7% 14.4% (9% diabetes+) median (interquartile range) 5 (5–10) years. In fully models, compared those no longer + group had lower diversity. significant differences across diabetes-related A significantly reduced butyrate-producing associated higher HOMA-IR (ex., Anaerostipes Lachnospiraceae_UCG.004 ), Agathobacter Ruminococcus Faecalibacterium Romboutsia ). Conclusions Our results that an adverse alteration related resistance, duration, present persons medications. These also levels certain bacteria produce health-promoting short‐chain fatty acids. Understanding role microbiota glucose regulation may provide new strategies reduce burden diabetes.