Overlap prevalence and interaction effect of cardiometabolic risk factors for metabolic dysfunction-associated steatotic liver disease

• DOI: 10.1186/s12986-025-00903-6
• Publication Date: 2025-02-11T16:00:36Z
• Authors: Dongying Zhao; Xiaoyan Zheng; Liwei Wang; Yujie Xie; Yan Chen; Yongjun Zhang
• Keywords: Clinical nutrition; Atherosclerotic cardiovascular disease

Cardiometabolic risk factors (CMRFs) related to metabolic dysfunction-associated steatotic liver disease (MASLD) comprised overweight/obesity, impaired glucose metabolism, hypertension, hypertriglyceridemia and low high-density lipoprotein cholesterol. We aimed describe the overlap prevalence synergistic interaction of five CMRFs on MASLD fibrosis. Using data 2017–2020 National Health Nutrition Examination Survey, we included non-pregnant participants aged ≥ 20 years who completed vibration-controlled transient elastography examinations had sufficient information determine their status. Logistic generalized linear regression models were performed assess between identify contributions The overall estimated was about 33.1%. More than 80% patients three or more CMRFs. For MASLD, pairs overweight/obesity other four higher it CMRFs' [attributable proportion(AP): 40–50% vs 20–30%]. fibrosis, metabolism hypertension significant interactions (AP: 50% 30%, respectively). identified 27 out 31 possible CMRF combinations. Combinations including dyslipidemia frequent in men women (77% 59%). less Mexican Americans ethnicities (25% 45–57%). Most combinations with CMRFs, regardless type, associations elevated stiffness value. quite common additive MASLD. Overlapping number may be important combination type fibrosis development.