Association of the interleukin-22 genetic polymorphisms with ulcerative colitis

• DOI: 10.1186/s13000-014-0183-y
• Publication Date: 2014-10-08T15:45:05Z
• Authors: Hong Gang Chi; Xue Bao Zheng; Zhu Guo Wu; Shi Xue Dai; Zheng Wan; Ying Zou
• Keywords: Adult; Male; 0301 basic medicine; Histology; Genotype; Research; Interleukins; Interleukin-22; Polymorphism, Single Nucleotide; Pathology and Forensic Medicine; 3. Good health; 03 medical and health sciences; Gene Frequency; Case-Control Studies; Odds Ratio; Humans; Colitis, Ulcerative; Female; Genetic Predisposition to Disease

Interleukin-22 (IL-22) is a member of the IL-10 family of anti-inflammatory cytokines that mediates epithelial immunity. IL-22 expression was found to be increased in patients with ulcerative colitis (UC). Whether genetic polymorphisms of IL-22 also influence UC risk is still unknown. The purpose of this study was to investigate the association between the IL-22 gene polymorphisms (-429 C/T, +1046 T/A and +1995 A/C) and the risk of UC in Chinese Han patients.This hospital-based case-control study comprised 180 patients with UC and 180 age- and gender-matched controls. Genotypes of 3 common polymorphisms of the IL-22 gene were determined by fluorogenic 5' exonuclease assays (TaqMan).Patients with UC had a significantly higher frequency of IL-22 -429 TT genotype [odds ratio (OR) =2.43, 95% confidence interval (CI) =1.35, 4.37; P=0.003] and -429 T allele (OR =1.54, 95% CI=1.14, 2.07; P=0.004) than controls. The findings are still emphatic by the Bonferroni correction. The IL-22+1046 T/A and IL-22+1995 A/C gene polymorphisms were not associated with a risk of UC. When stratifying by clinical type, location and disease severity of UC, no significant differences were found in any groups.This is the first study to provide evidence for an association of IL-22 -429 C/T gene polymorphisms with UC risk. Additional well-designed large studies were required for the validation of our results.The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/13000_2014_183.