Integration of BOLD-fMRI and DTI into radiation treatment planning for high-grade gliomas located near the primary motor cortexes and corticospinal tracts

• DOI: 10.1186/s13014-015-0364-1
• Publication Date: 2015-03-07T22:59:39Z
• Authors: Minglei Wang; Hui Ma; Xiaodong Wang; Yanhong Guo; Xinshe Xia; Hechun Xia; Yulin Guo; Xueying Huang; Hong He; Xiaoxiong Jia; Yan Xie
• Keywords: Adult; Male; Diffusion tensor imaging (DTI); Pyramidal Tracts; Young Adult; 03 medical and health sciences; 0302 clinical medicine; Humans; Radiation treatment planning; High-grade gliomas; Aged; Brain Neoplasms; Research; Radiotherapy Planning, Computer-Assisted; Motor Cortex; Radiotherapy Dosage; Glioma; Middle Aged; Prognosis; Magnetic Resonance Imaging; Intensity-modulated radiation therapy (IMRT); Diffusion Tensor Imaging; Oncology; Radiology Nuclear Medicine and imaging; Blood oxygen level dependent functional magnetic resonance imaging (BOLD-fMRI); Female; Radiotherapy, Intensity-Modulated; Neoplasm Grading; Three-dimensional conformal radiation treatmen; Follow-Up Studies

The main objective of this study was to evaluate the efficacy integrating blood oxygen level dependent functional magnetic resonance imaging (BOLD-fMRI) and diffusion tensor (DTI) data into radiation treatment planning for high-grade gliomas located near primary motor cortexes (PMCs) corticospinal tracts (CSTs). A total 20 patients with adjacent PMCs CSTs between 2012 2014 were recruited. bilateral in normal regions without any overlapping target volume lesions. BOLD-fMRI, DTI conventional MRI performed on (Karnofsky performance score ≥ 70) before radical radiotherapy treatment. Four different studies conducted each patient: a computed tomography (CT), an anatomical MRI, BOLD-fMRI. For case, three plans (3DCRT, IMRT IMRT_PMC&CST) developed by 3 physicists using Pinnacle system. Our has shown that there no significant difference 3DCRT terms dose homogeneity, but displayed better (PTV) conformity. In addition, we have found Dmax Dmean ipsilateral contralateral PMC CST considerably decreased IMRT_PMC&CST group (p < 0.001). conclusion, integration BOLD-fMRI is feasible beneficial. With assistance above-described techniques, could be clearly marked as OARs spared during