A preliminary study of osteochondral regeneration using a scaffold-free three-dimensional construct of porcine adipose tissue-derived mesenchymal stem cells

• DOI: 10.1186/s13018-015-0173-0
• Publication Date: 2015-03-17T09:34:56Z
• Authors: Daiki Murata; Satoshi Tokunaga; Tadashi Tamura; Hiroaki Kawaguchi; Noriaki Miyoshi; Makoto Fujiki; Koichi Nakayama; Kazuhiro Misumi
• Keywords: Fibrocartilage; Endochondral ossification; Chondrogenesis; CD90; Histopathology

Osteoarthritis (OA) is a major joint disease in humans and many other animals. Consequently, medical countermeasures for OA have been investigated diligently. This study was designed to examine the regeneration of articular cartilage subchondral bone using three-dimensional (3D) constructs adipose tissue-derived mesenchymal stem cells (AT-MSCs).