Moderate ethanol exposure disrupts energy homeostasis between central and peripheral system in APP/PS1 mice

• DOI: 10.1186/s13041-025-01192-z
• Publication Date: 2025-03-17T11:02:21Z
• Authors: Shinwoo Kang; Jeyeon Lee; Paul H. Min; Doo-Sup Choi

Abstract To investigate the effects of moderate ethanol exposure on glucose metabolism in APP/PS1 mice, an early-onset Alzheimer’s disease (AD) mouse model, we employed an fluoro-deoxy-glucose (FDG)-micro-positron emission tomography (PET). We also utilized the comprehensive lab animal monitoring system (CLAMS) to measure whole-body energy expenditure and respiratory exchange ratio (RER). We found that ethanol exposure increased glucose metabolism in the brain as measured by FDG-PET. Also, CLAMS data indicated a decrease in RER, suggesting a shift toward fat utilization as the primary energy source. Following ethanol exposure in APP/PS1 mice, these findings reveal a distinct metabolic difference between brain and peripheral tissues.