Association between morphologic grading and implantation rate of Euploid blastocyst

• DOI: 10.1186/s13048-021-00770-8
• Publication Date: 2021-01-23T16:03:22Z
• Authors: Hua Lou; Na Li; Yichun Guan; Yuchao Zhang; Dayong Hao; Shihong Cui
• Keywords: Embryo quality; Grading (engineering)

Abstract Background Standard morphologic evaluation has been the most widely adopted approach to embryo selection, and remains common strategy.The objective of study determine association between grading implantation rate euploid blastocysts in single frozen-thawed transfer (SET) cycles. Methods A total 271 patients aged 20–40 years undergoing SET from January 2017 December 2019 were included retrospective cohort . The cycles divided into three groups based on their before cryopreservation: good-quality ( n = 58), average-quality 88) poor-quality 125). pregnancy outcome analyzed a logistic regression was conducted. Results Good-quality yielded statistically significantly higher rates than (79.31% vs. 48%; P <0.001). Planned subgroup analyses by age day TE biopsy Logistic that adjusted for these variables identified (adjusted odds ratio(aOR) 4.083, 95% confidence interval (CI):1.836–9.082, <0.001) those underwent women < 35 years, but not ≥35 (aOR 6.074, CI: 0.456–80.919, 0.172). among with both Day 5 6 (Day 5, aOR 3.294, CI:1.260–8.616, 0.015; 6, 4.179, CI:1.004 ~ 17.399, 0.049). had no significant difference potential early spontaneous abortion compared similarly graded blastocysts. Conclusions Blastocyst associated transfers after adjustment confounders. These findings suggest evaluating blastocyst morphology is critical when selecting best blastocyst.