The prognostic factor for recurrence in advanced-stage high-grade serous ovarian cancer after complete clinical remission: a nested case-control study

• DOI: 10.1186/s13048-021-00908-8
• Publication Date: 2021-12-20T18:02:45Z
• Authors: Qiao Wang; Ying Zheng; Ping Wang; Jiawen Zhang; Hui Liu; Qingli Li; Rutie Yin; Ce Bian; Hongling Peng; Zhilan Peng
• Keywords: Univariate analysis; Serous ovarian cancer

Women with advanced-stage high-grade serous ovarian cancer (HGSOC) are likely to have a bad prognosis. Relapses common in patients even no evidence of disease after primary treatment. We aimed identify the prognostic factors for recurrence these patients.A nested case-control study was conducted large medical center Southwest China. The outcome within 3 years clinical remission (CR). Cox regression used calculate time event analysis different groups.Ninety-seven were finally included. Fifty-seven (58.8%) relapsed CR. Among all variables, difference posttreatment CA-125 level statistically significant (P <0.05) between recurrent group and progression-free both univariate multivariable analysis. A cutoff value set at median (10 U/ml) categorize into two arms. In regression, identified as factor an OR 1.05 (95% CI: 1.02-1.10, P = 0.033). (from initiation treatment) until relapse 25 months whose levels higher than 10 U/ml, while it undefined ≤ U/ml. Patients showed increased risk OC compared those lower level. Furthermore, shown line graphs recording serum during follow-up each case, increments delayed who had CA125 U/ml level.A low treatment potential women advanced HGSOC.