Does the addition of metformin to carboplatin treatment decreases ovarian reserve damage associated with carboplatin usage?

• DOI: 10.1186/s13048-023-01259-2
• Publication Date: 2023-09-02T10:01:52Z
• Authors: Sevgi Ayhan; Necati Hancerliog...; Gurhan Guney; Murat Gozukucuk; Muzaffer Caydere; Sergul Selvi Guney; Aytekin Tokmak; Yusuf Ustun
• Keywords: Carboplatin; Ovarian Reserve

Abstract Background We aimed to determine whether adding metformin carboplatin treatment would reduce the damage ovarian reserve associated with use. Methods included 35 adult female non-pregnant albino Wistar rats approximately three months old, weighing 220–310 g. The were divided into five groups of seven according they received. Carboplatin and salin was given Group 2, plus 3. 4 administered only metformin. 5 salin. Groups 2 3 as a single dose on 15th day, while during 28-day experiment. After oophorectomy, histopathologic analyses primordial, primary, secondary, tertiary Graff follicles epithelial cells surrounding oocyte total follicular number conducted per section. Serum Anti-Mullerian Hormone (AMH), tissue catalase, malonyl dialdehyde levels measured compared within each group. Results baseline 15th-day serum AMH values menstrual cycle among groups, no statistically significant differences observed (p > 0.05). 3, which both metformin, had significantly higher 28th-day than saline < 0.001). primordial in found be Tissue catalase enzyme malondialdehyde Conclusions Metformin may attenuate carboplatin-induced damage, possibly through its antioxidative effects.