Upregulation of Nox4 induces a pro-survival Nrf2 response in cancer-associated fibroblasts that promotes tumorigenesis and metastasis, in part via Birc5 induction

• DOI: 10.1186/s13058-022-01548-6
• Publication Date: 2022-07-14T09:05:04Z
• Authors: Shakeel Mir; Briana D. Ormsbee...; Brandon J. Griess; Raghupathy Vengoji; Eric Tom; Elizabeth A. Kosm...; Rebecca E. Oberle...; Geoffrey A. Talmon; Vimla Band; Melissa LT. Teoh-...
• Keywords: NOX4; Surgical oncology

A pro-oxidant enzyme, NADPH oxidase 4 (Nox4) has been reported to be a critical downstream effector of TGFβ-induced myofibroblast transformation during fibrosis. While there are small number studies suggesting an oncogenic role Nox4 derived from activated fibroblasts, direct evidence linking this the tumor-supporting CAF phenotype and mechanisms involved lacking, particularly in breast cancer.