The goose genome sequence leads to insights into the evolution of waterfowl and susceptibility to fatty liver

• DOI: 10.1186/s13059-015-0652-y
• Publication Date: 2015-05-05T08:50:19Z
• Authors: Lizhi Lu; Yan Chen; Zhuo Wang; Xiaofeng Li; Weihu Chen; Zhengrong Tao; Junda Shen; Yong Tian; Deqian Wang; Guoqin Li; Li Chen; Fang Chen; Dongming Fang; Lili Yu; Yudong Sun; Yong Ma; Jinjun Li; Jun Wang
• Keywords: Human genetics; Sequence (biology)

Geese were domesticated over 6,000 years ago, making them one of the first poultry. are capable rapid growth, disease resistance, and high liver lipid storage capacity, can be easily fed coarse fodder. Here, we sequence analyze whole-genome an economically important goose breed in China compare it with that terrestrial bird species.A draft whole-goose genome was obtained by shotgun sequencing, 16,150 protein-coding genes predicted. Comparative genomics indicate significant differences occur between other species, particularly regarding major histocompatibility complex, Myxovirus Retinoic acid-inducible gene I, related to resistance geese. In addition, analysis transcriptome data further reveals a potential molecular mechanism involved susceptibility geese fatty its associated symptoms, including levels unsaturated acids low cholesterol. The results this study show deletion lep might result positive selection, thus allowing adopt energy mechanisms for long-distance migration.This is report describing complete contributes genomic resources available studying aquatic birds. findings useful not only genetic breeding programs, but also metabolism disorders.