Bacteriophage infections of microbiota can lead to leaky gut in an experimental rodent model

• DOI: 10.1186/s13099-016-0109-1
• Publication Date: 2016-06-23T15:24:16Z
• Authors: George Tetz; Victor Tetz
• Keywords: Intestinal Permeability; Lactulose; Medical microbiology; Bacterial translocation; Vascular permeability

Increased intestinal permeability and translocation of gut microbiota from the lumen to systemic circulation predispose patients various diseases may be one main triggers thereof. The role in increased is under intensive investigation. Here, we studied alterations host as a direct effect treatment with bacteriophage cocktail. After 10 days challenge, rats showed weight loss, messy hair, decreased activity. Additionally, they displayed significantly elevated lactulose:mannitol ratio level circulating immune complexes. To our knowledge, this study demonstrates for first time that induced by bacteriophages affect microbiota.