Detrimental relevance of Helicobacter pylori infection with sarcopenia

• DOI: 10.1186/s13099-021-00464-y
• Publication Date: 2021-11-15T12:03:01Z
• Authors: Shou-En Wu; Wei-Liang Chen
• Keywords: CagA; Medical microbiology

Abstract Background Helicobacter pylori ( H. ), Gram negative microaerophilic bacteria, is a well-known pathogen of many gastrointestinal diseases. But several emerging evidences suggest it role in numerous other extra-gastric The current study investigates the relationship between infection and sarcopenia, clinical condition characterized by loss mass function skeletal muscle. A total 3453 eligible participants from Third National Health Nutrition Examination Survey (NHANES III), United States, were enrolled. Based on serum laboratory results, subjects categorized into three groups: normal (without evidence any infection), anti- IgG positive [ (+)], concurrent anti-cytotoxin-associated gene [CagA (+)]. Sarcopenia was determined as having muscle index (SMI) value that more than 1 standard deviation away mean sex-specific, healthy young adults 20 39 years old. Risk sarcopenia its components are compared subgroups. Results Odds ratios (OR) for confirmed diagnosis higher (+) (OR = 2.052, 95% CI 1.697–2.481, p < 0.001) CagA 1.585, 1.278–1.965, groups. Moreover, beta regression coefficient SMI shown (β: − 0.023, 0.017, 0.001). Sub-analyses which gender revealed absolute female subgroup 1.745 male 2.942 female, both 0.001), 1.407 2.159 Conclusions Positive infectious markers including antibody seropositivity correlated with low quantity. Therefore, eradication therapy may bring benefits to patients active infection.