Virulence factors and mechanisms of paediatric pneumonia caused by Enterococcus faecalis

• DOI: 10.1186/s13099-022-00522-z
• Publication Date: 2023-01-09T14:04:27Z
• Authors: Zhiying Tian; Asif Iqbal Khan; Ata Ur Rehman; Ting Deng; Chao Ma; Liang Wang
• Keywords: Enterococcus faecalis; Virulence factor

Abstract Paediatric pneumonia is a respiratory infection that affects infants and young children under the age of 3. This disease leading cause infant child mortality in developing countries because weak immune system children. The difficulty length time required to identify pathogen causative agent are main reasons for this high rate. In addition, identification certain agents particularly important treatment paediatric pneumonia. study, we explored possible mechanisms by which pathogenic Enterococcus faecalis induced vivo. potential virulence factors bacteria isolated from intestines patients were determined. Taken together, results suggested lysophosphatidic acid (LTA) E. decreases expression platelet-activating factor receptor (PAFR), turn disrupts function intestinal tight junctions (Occ Ccldn1), entry LE-LTA into bloodstream disruption barrier. Although LTA can enter circulation, it cannot directly infiltrate lungs, indicates lung inflammation mice not caused direct lungs. We further found activates cells, such as CD8 + T cells type 2 innate lymphocytes, Interleukin-6 interleukin-17 produce large amounts inflammatory thus promote development conclusion, our findings demonstrate intestine study bacterial induce responses lungs blood. These could provide insight mechanism infectious diseases intestine.