Profile of copper-associated DNA methylation and its association with incident acute coronary syndrome

• DOI: 10.1186/s13148-021-01004-w
• Publication Date: 2021-01-27T01:02:29Z
• Authors: Pinpin Long; Qiuhong Wang; Yizhi Zhang; Xiaoyan Zhu; Kuai Yu; Haijing Jiang; Xuezhen Liu; Min Zhou; Yu Yuan; Kang Liu; Jing Jiang; Xiaomin Zhang; Meian He; Huan Guo; Weihong Chen; Jing Yuan; Longxian Cheng; Liming Liang; Tangchun Wu
• Keywords: Adult; Aged, 80 and over; Male; 0301 basic medicine; China; Research; Age Factors; Gene Expression; DNA Methylation; Middle Aged; Epigenesis, Genetic; 3. Good health; 03 medical and health sciences; Asian People; Case-Control Studies; Humans; Female; Acute Coronary Syndrome; Copper; Aged; Genome-Wide Association Study

Abstract Background Acute coronary syndrome (ACS) is a cardiac emergency with high mortality. Exposure to copper (Cu) concentration has been linked ACS. However, whether DNA methylation contributes the association between Cu and ACS unclear. Methods We measured level at > 485,000 cytosine-phosphoguanine sites (CpGs) of blood leukocytes using Human Methylation 450 Bead Chip conducted genome-wide meta-analysis plasma in total 1243 Chinese individuals. For Cu-related CpGs, we evaluated their associations expression nearby genes as well major cardiovascular risk factors. Furthermore, examined longitudinal incident nested case-control study. Results identified four novel Cu-associated CpGs (cg20995564, cg18608055, cg26470501 cg05825244) within 5% false discovery rate ( FDR ). cg26470501, cg05825244 also showed significant correlations expressions SBNO2 , BCL3 EBF4 gene, respectively. Higher locus was associated lower high-density lipoprotein cholesterol higher C-reactive protein level. demonstrated that increased (odds ratio [OR], 1.23; 95% CI 1.02–1.48; P = 0.03). Conclusions alterations populations these loci ACS, providing new insights into regulation gene by suggesting role for