Comprehensive analysis of PD-L1 expression, tumor-infiltrating lymphocytes, and tumor microenvironment in LUAD: differences between Asians and Caucasians

• DOI: 10.1186/s13148-021-01221-3
• Publication Date: 2021-12-21T15:09:56Z
• Authors: Fenglong Bie; He Tian; Nan Sun; Ruochuan Zang; Moyan Zhang; Peng Song; Lei Liu; Yue Peng; Guangyu Bai; Bolun Zhou; Shugeng Gao
• Keywords: Tumor-infiltrating lymphocytes

Abstract Backgrounds The characteristics of programmed cell death protein-1 (PD-L1) expression, tumor-infiltrating lymphocytes (TILs), and tumor microenvironment (TME) in lung adenocarcinoma (LUAD) patients are closely related to immunotherapy, there differences between Asians Caucasians. Methods Acquire the transcriptome data Cancer Genome Atlas Chinese LUAD patients. R software was used analyze differential expression genes, prognosis, gene function. Use CIBERSORT for TIL-related analysis ESTIMATE TME-related analysis. Results PD-L1 tissues Caucasian lower than that normal tissues, while no significant difference Asians. There statistical prognosis. composition TILs Asian quite different. correlation prognosis However, higher content resting mast cells indicated a better with immune estimate scores had ( p = 0.021, 0.025). score worse 0.024). high COL5A2 0.046, 0.027) NOX4 0.020, 0.019) were both associated poor Caucasians Conclusion many TILs, TME This provides certain hint selection specific immunotherapy strategies separately