Cell-specific extracellular vesicle-encapsulated exogenous GABA controls seizures in epilepsy

• DOI: 10.1186/s13287-024-03721-4
• Publication Date: 2024-04-19T00:01:41Z
• Authors: Abhijna Ballal R; Shivakumar Reddy K; Divya Chandran; Sumukha Hegde; Raghavendra Upadhya; Praveen Kumar SE; Smita Shenoy; Vasudha Devi; Dinesh Upadhya
• Keywords: Gamma-Aminobutyric Acid; Ganglionic eminence

Epilepsy affects ∼60 million people worldwide. Most antiseizure medications in the market act on voltage-gated sodium or calcium channels, indirectly modulating neurotransmitter GABA glutamate levels multiple targets. Earlier studies made significant efforts to directly deliver into brain with varied success. Herein, we have hypothesized exogenous epilepsy through extracellular vesicles (EVs) from human GABA-producing cells and their progenitors as EVs largely mimic parent cell composition.