Effect of enriched housing on levels of natural (auto-)antibodies in pigs co-infected with porcine reproductive and respiratory syndrome virus (PRRSV) and Actinobacillus pleuropneumoniae

• DOI: 10.1186/s13567-017-0481-y
• Publication Date: 2017-11-10T12:05:06Z
• Authors: Lu Luo; Ingrid Daniëlle E...; Inonge Reimert; Bas Kemp; Jantina Elizabeth...; Hendrik Karel Par...
• Keywords: Actinobacillus pleuropneumoniae; Keyhole limpet hemocyanin; Immunoglobulin M

Housing of pigs in barren, stimulus-poor housing conditions may influence their immune status, including antibody responses to (auto-)antigens, and thus affect protection, which will the onset outcome infection. In present study, we investigated effects environmental enrichment versus barren on level natural (auto-)antibodies (NA(A)b) isotypes (IgM IgG) binding keyhole limpet hemocyanin (KLH), myelin basic protein (MBP), phosphorycholine conjugated bovine serum albumin (PC-BSA) co-infected with porcine reproductive respiratory syndrome virus (PRRSV) Actinobacillus pleuropneumoniae (A. pleuropneumoniae). Pigs (n = 56) were housed either or enriched pens from birth 54 days age. They infected PRRSV 44 age, A. 8 later. Blood samples taken 7 different sampling days. significantly affected overall levels NA(A)b KLH, MBP PC-BSA, before infection had higher than pigs, except for KLH-IgM PC-BSA-IgG. Infection only IgM, but not IgG isotype. Moreover, changes MBP-IgM PC-BSA-IgM following pigs. These results suggest that effect is influenced by NA(A)b, especially IgM be