Virus persistence in pig herds led to successive reassortment events between swine and human influenza A viruses, resulting in the emergence of a novel triple-reassortant swine influenza virus

• DOI: 10.1186/s13567-019-0699-y
• Publication Date: 2019-10-07T13:19:37Z
• Authors: Amélie Chastagner; Emilie Bonin; Christelle Fablet; Stéphane Quéguiner; Edouard Hirchaud; Pierrick Lucas; Stéphane Gorin; Nicolas Barbier; Véronique Béven; Emmanuel Garin; Yannick Blanchard; Nicolas Rose; Séverine Hervé; Gaëlle Simon
• Keywords: Reassortment; Persistence (discontinuity); Biosecurity; Pandemic

This report describes the detection of a triple reassortant swine influenza A virus H1avN2 subtype. It evolved from an avian-like H1avN1 that first acquired N2 segment seasonal H3N2, then M 2009 pandemic H1N1, in two reassortments estimated to have occurred 10 years apart. study illustrates how recurrent infections increase co-infection risk and facilitate evolutionary jumps by successive gene exchanges. recalls importance appropriate biosecurity measures inside holdings limit persistence interspecies transmissions, which both contribute emergence new potentially zoonotic viruses.