Galectin from Trichinella spiralis alleviates DSS-induced colitis in mice by regulating the intestinal microbiota

• DOI: 10.1186/s13567-023-01262-x
• Publication Date: 2024-01-03T11:01:58Z
• Authors: Jianqing Li; Xiangjiang Wang; Qiuhui Wang; Yishen Hu; Shouan Wang; Jia Xu; Jianbin Ye
• Keywords: Trichinella spiralis

Abstract According to numerous reports, Trichinella spiralis ( T. ) and its antigens can reduce intestinal inflammation by modulating regulatory immunological responses in the host maintain immune homeostasis. Galectin has been identified as a protein that is produced , characterization revealed this possible activity. However, whether recombinant galectin rTs -gal) cure dextran sulfate sodium (DSS)-induced colitis remains unknown. Here, ability of -gal ameliorate experimental mice with inflammatory bowel disease (IBD) well potential underlying mechanism were investigated. The activity index (DAI), colon shortening, cell infiltration, histological damage used indicators monitor clinical symptoms colitis. results administration ameliorated these symptoms. Western blotting ELISA results, may suppress excessive response-mediated induction TLR4, MyD88, NF-κB expression colon. Mice exhibit disruptions gut flora, including an increase gram-negative bacteria, which turn result increased lipopolysaccharide (LPS) production. injection inhibit changes microbiota, for example, reducing prevalence Helicobacter Bacteroides produce LPS. findings present study signalling pathways involve enteric bacteria-derived LPS, DSS-induced attenuate animals microbiota. These shed additional light on processes beneficial effects helminth-derived proteins medicine.