Emergence and genomic characterization of Proteus mirabilis harboring blaNDM-1 in Korean companion dogs

• DOI: 10.1186/s13567-024-01306-w
• Publication Date: 2024-04-09T13:03:13Z
• Authors: Su Min Kyung; Jun Ho Lee; Eun-Seo Lee; Xi-Rui Xiang; Han Sang Yoo
• Keywords: Molecular Epidemiology

Abstract Proteus mirabilis is a commensal bacterium dwelling in the gastrointestinal (GI) tract of humans and animals. Although New Delhi metallo-β-lactamase 1 (NDM-1) producing P. emerging as threat, its epidemiology our society remains largely unknown. LHPm1, first isolate harboring NDM-1, was detected from companion dog that resides with human owner. The whole-genome study revealed 20 different antimicrobial resistance (AMR) genes against various classes agents, which corresponded to MIC results. Genomic regions, including MDR genes, were identified multiple variations visualized comparative manner. In epidemiological analysis, phylogroups identified, revealing genetic relationship LHPm1 other strains carrying AMR genes. These findings offer comprehensive insights into NDM-1-producing , underscoring need for urgent control measures surveillance programs using “one health approach”.