Early risk factors and the role of fluid administration in developing acute respiratory distress syndrome in septic patients

• DOI: 10.1186/s13613-017-0233-1
• Publication Date: 2017-01-23T13:12:45Z
• Authors: Raghu R. Seethala; Peter C. Hou; Imoigele P. Aisiku; Gyorgy Frendl; Pauline K. Park; Mark E. Mikkelsen; Steven Y. Chang; Ognjen Gajic; Jonathan Sevransky
• Keywords: Pain medicine

Sepsis is a major risk factor for acute respiratory distress syndrome (ARDS). However, there remains paucity of literature examining factors ARDS in septic patients early their course. This study examined the role fluid administration and identified other within first 6 h hospital presentation associated with developing patients. was secondary analysis adult presenting to Emergency Department or being admitted high-risk elective surgery from multicenter observational cohort study, US Critical Injury Illness trial Group-Lung Prevention Study 1 (USCIITG-LIPS 1, NCT00889772). Multivariable logistic regression performed identify potential ARDS. Stratified by shock status examine association between Of 5584 original cohort, 2534 (45.4%) met our criteria sepsis. One hundred fifty-six (6.2%) these developed during stay. In multivariable analyses, Acute Physiology Chronic Health Evaluation (APACHE) II score (OR 1.10, 95% CI 1.07–1.13), age 0.97, 0.96–0.98), total infused (in liters) 1.15, 1.03–1.29), 2.57, 1.62–4.08), pneumonia as site infection 2.31, 1.59–3.36), pancreatitis 3.86, 1.33–11.24), abdomen 3.77, 1.37–10.41) were stratified analysis, 1.05, 0.87–1.28) not development group, while an non-shock group 1.21, 1.05–1.38). patients, following ARDS: APACHE score, presence shock, pulmonary source infection, pancreatitis, abdomen. without amount