Influence of antibiotic pressure on multi-drug resistant Klebsiella pneumoniae colonisation in critically ill patients

• DOI: 10.1186/s13756-019-0484-8
• Publication Date: 2019-02-14T09:06:04Z
• Authors: Jesus Ruiz; Monica Gordon; Esther Villarreal; Juan Frasquet; María Ángeles Sán...; María Martín; Álvaro Castellanos; Paula Ramirez
• Keywords: Colonisation

The aim of this study is to evaluate the risk factors for colonisation by multidrug resistant (MDR) K. pneumoniae in a critical care unit and relationship between antibiotic pressure exerted antimicrobial treatments received patients. A prospective observational was designed. Patients admitted more than 48 h an intensive were included. Samples surveillance cultures obtained from all patients upon admission once week. association MDR determined logistic regression. Cox regression model used effect use antimicrobials on rate. An ARMIA investigate incidence strains global consumption unit. One thousand seven hundred twenty-five included, which 308 (17.9%) positive pneumoniae. In multivariate analysis, hospitalisation longer 7 days together with respiratory infection administration any associated increased MR colonisation. who antibiotics colonised earlier did not receive treatment [HR: 2.16 (95%CI:1.55–3.03)]. ARIMA found significant monthly rate cephalosporins carbapenems previous month. Individual are strains.