First case of low-dose umbilical cord blood therapy for pediatric acute respiratory distress syndrome induced by Pneumocystis carinii pneumonia

• DOI: 10.1186/s40001-021-00548-0
• Publication Date: 2021-08-28T04:02:48Z
• Authors: Shuang Liu; Huili Shen; Siyuan Huang; Rong Liu; Dong Qu
• Keywords: Male; 0301 basic medicine; Respiratory Distress Syndrome; Acute respiratory distress syndrome; Pneumocystis carinii pneumonia; Pneumonia, Pneumocystis; R; Case Report; Fetal Blood; Pneumocystis carinii; Prognosis; Respiration, Artificial; 3. Good health; Umbilical cord blood; 03 medical and health sciences; Extracorporeal Membrane Oxygenation; Medicine; Humans; Transplantation, Homologous; Cord Blood Stem Cell Transplantation; Child

This study aimed to present the case of a boy with acute distress syndrome (ARDS) treated low-dose umbilical cord blood (UCB) therapy and explore underlying possible mechanism.A 7-year-old severe Pneumocystis carinii pneumonia ARDS was allogeneic UCB as salvage therapy.The patient did not improve after being lung protective ventilation, pulmonary surfactant replacement, extracorporeal membrane oxygenation (ECMO) for 30 days. However, his disease reversed 5 days infusion, he weaned from ECMO 7 infusion. Bioinformatics confirmed that Toll-like receptor (TLR) abnormal before immune system activated repaired, TLR4/MyD88/NF-κB signaling pathway recovered.Allogenic could treat by repairing pathway, thereby achieving stability system.