No causal association between allergic rhinitis and migraine: a Mendelian randomization study

• DOI: 10.1186/s40001-024-01682-1
• Publication Date: 2024-01-27T09:02:22Z
• Authors: Hao Lv; Kunyu Liu; Yulie Xie; Yunfei Wang; Siyuan Chen; Peiqiang Liu; Mengting Guan; Jianchao Cong; Yu Xu
• Keywords: Mendelian Randomization; Association (psychology); Migraine Disorders

Allergic rhinitis (AR) and migraine are among the most common public health problems worldwide. Observational studies on correlation between AR have reported inconsistent results. This study aimed to investigate causal relationship of with its subtypes, including aura (MA) without (MO). Bidirectional two-sample Mendelian randomization (MR) analysis was performed publicly available summary-level statistics large genome-wide association estimate possible effects. The inverse variance-weighted method selected for primary supplemented weighted median, mode, MR-Egger methods. using summary effect estimates (CAUSE) were further verify causality. Several sensitivity tests, leave-one-out, Cochran's Q, intercept, MR-PRESSO assess robustness did not exhibit a significant elevated risk any (odd ratio (OR), 0.816; 95% confidence interval (CI), 0.511-1.302; P = 0.394), MA (OR, 0.690; CI 0.298-1.593; 0.384), or MO 1.022; 0.490-2.131; 0.954). Consistently, reverse MR reveal effects subtypes AR. Almost all analyses supported clear risk. More research is warranted complex migraine.