Mining the key regulatory genes of chicken inosine 5′-monophosphate metabolism based on time series microarray data

• DOI: 10.1186/s40104-015-0022-3
• Publication Date: 2015-05-22T15:18:32Z
• Authors: Teng Ma; Lu Xu; Hongzhi Wang; Jing Chen; Lu Liu; Guobin Chang; Guohong Chen
• Keywords: Inosine monophosphate

IMP (inosine 5'-monophosphate) is a compound that enhances the flavor of poultry meat. has become new breeding trait to improve meat quality. We tried identify several potential regulatory genes, and construct their predicted relationships. Time series gene expression profiles thigh muscle tissues Rugao chicken, famous indigenous breed in China, were performed for analysis genes are co-expressed or correlated with concentration IMP. found 15 crucial co-expression which Hspa2, Pten, Gabpa, Bpi, Mkl1, Srf, Cd34, Hspa4, Etv6, Bmpr2, Gde1, Igfbp5, Cd28, Pecam1 Gja1, may directly indirectly regulate metabolism. Eventually, we computed correlation coefficient between 19 Genes CGs (15 genes), identified constructed regulation network. In conclusion, variation was primarily connected development process. During this process, have significant influence on particular, Pten Entpd8 might play important roles regulating de novo synthesis, decomposition salvage synthesis.