Probiotic Lactobacillus rhamnosus GG improves insulin sensitivity and offspring survival via modulation of gut microbiota and serum metabolite in a sow model

• DOI: 10.1186/s40104-024-01046-z
• Publication Date: 2024-07-02T00:02:18Z
• Authors: Tianle Gao; Ran Li; Liang Hu; Quanfang Hu; Hongmei Wen; Rui Zhou; Peiqiang Yuan; Xiaoling Zhang; Lingjie Huang; Yong Zhuo; Shengyu Xu; Yan Lin; Bin Feng; Lianqiang Che; De Wu; Zhengfeng Fang
• Keywords: Lactobacillus rhamnosus

Abstract Background Sows commonly experience insulin resistance in late gestation and lactation, causing lower feed intake milk production, which can lead to higher mortality rates newborn piglets. The probiotic Lactobacillus rhamnosus GG (LGG) is known improve resistance. However, whether supplementing LGG sensitivity sows enhance lactation performance, particularly the early survival of offspring remains unclear. Hence, we explored effects mechanisms during on sow sensitivity, survival. In total, 20 were randomly allocated an ( n = 10) control group 10). Results sows, supplementation significantly improved increased intake, production colostrum lactose levels enhanced piglet Moreover, treatment reshaped gut microbiota notably increasing diversity enriching relative abundance sensitivity-associated probiotics such as , Bifidobacterium Bacteroides . Serum metabolite amino acid profiling late-gestation also revealed decreased branched-chain kynurenine serum following supplementation. Further analyses highlighted a correlation between mitigated pregnancy by reshaping changes metabolism. Furthermore, maternal immunity piglets, reduced inflammation, facilitated establishment microbiota. Conclusions We provide first evidence that mitigates enhances modulating