A single bacterium restores the microbiome dysbiosis to protect bones from destruction in a rat model of rheumatoid arthritis

• DOI: 10.1186/s40168-019-0719-1
• Publication Date: 2019-07-17T15:02:42Z
• Authors: Hudan Pan; Ruijin Guo; Yanmei Ju; Qi Wang; Jie Zhu; Ying Xie; Yanfang Zheng; Ting Li; Zhongqiu Liu; Linlin Lu; Fei Li; Bin Tong; Liang Xiao; Xun Xu; Elaine Lai-Han Leung; Runze Li; Huanming Yang; Jian Wang; Hua Zhou; Huijue Jia; Liang Liu
• Keywords: Lactobacillus casei; Dysbiosis; Lactobacillus reuteri

Early treatment is key for optimizing the therapeutic success of drugs, and current initiating that blocks progression bone destruction during pre-arthritic stages remains unsatisfactory. The microbial disorder in rheumatoid arthritis (RA) patients significantly reversed with effective treatment. Modulating aberrant gut microbiomes into a healthy state potential approach preventing damage. By using metagenomic shotgun sequencing metagenome-wide association study, we assessed effect Lactobacillus casei (L. casei) on induction as well associated microbiota immune disorders adjuvant-induced (AIA) rats. Treatment AIA rats L. inhibited joint swelling, lowered scores, prevented destruction. Along relief symptoms, dysbiosis microbiome arthritic was reduced after intervention. relative abundance AIA-decreased strains, including hominis, reuteri, vaginalis, were restored to normal acidophilus upregulated by administration Moreover, downregulated expression pro-inflammatory cytokines, which are closely linked treatment-associated microbes. Functionally, maintenance redox balance oxidative stress involved improvement casei-treated A single bacterium, (ATCC334), able suppress protect bones from restoring gut, indicating probiotics may be promising strategy treating RA, especially early stage disease.