Fecal microbiota transfer between young and aged mice reverses hallmarks of the aging gut, eye, and brain

• DOI: 10.1186/s40168-022-01243-w
• Publication Date: 2022-05-03T02:02:43Z
• Authors: Aimée Parker; Stefano Romano; Rebecca Ansorge; Asmaa Aboelnour; Gwenaelle Le Gall; George M. Savva; Matthew G. Pontifex; Andrea Telatin; David Baker; Emily Jones; David Vauzour; Steven Rudder; L. Ashley Blackshaw; Glen Jeffery; Simon R. Carding
• Keywords: Gut–brain axis; Brain Function; Aging brain; Healthy aging; Fecal bacteriotherapy

Altered intestinal microbiota composition in later life is associated with inflammaging, declining tissue function, and increased susceptibility to age-associated chronic diseases, including neurodegenerative dementias. Here, we tested the hypothesis that manipulating influences development of major comorbidities aging and, particular, inflammation affecting brain retina.