Lactobacillus reuteri improves the development and maturation of fecal microbiota in piglets through mother-to-infant microbe and metabolite vertical transmission

• DOI: 10.1186/s40168-022-01336-6
• Publication Date: 2022-12-02T09:27:25Z
• Authors: Gang Wang; Xinyu Wang; Yonghang Ma; Shuang Cai; Lijie Yang; Yuxin Fan; Xiangfang Zeng; Shiyan Qiao
• Keywords: Lactobacillus reuteri; Ruminococcus; Metabolome

Abstract Background The immature neonatal fecal microbiota substantially impacts the development of gut health and greatly increases risk disease. Developing effective strategies to modulate has great significance. Herein, we investigated whether maternal dietary supplementation oral administration Lactobacillus reuteri could effectively promote maturation microbiome in piglets from birth weaning. Results Metagenomic analysis colostrum showed that L. influenced overall composition, decreased abundance phylum Proteobacteria increased species Bifidobacterium choerinum . KEGG pathway revealed enriched lysine biosynthesis glycolysis/gluconeogenesis pathways downregulated bacterial invasion epithelial cells colostrum. In addition, significantly altered metabolite features modules umbilical cord blood serum based on metabolomics. Further, a significant covariation was observed between these differential metabolites Maternal also composition meconium beneficial bacteria (such as Romboutsia , Blautia Butyricicoccus Ruminococcus ), some which were markedly associated with several two groups. Notably, both intake had strong microbial during early life, effects dependent growth stage. Oral promoted diarrhea resistance neonates, while enhanced abilities antioxidants inflammation. Moreover, via methods combination improved performances piglets. Conclusion Overall, our data demonstrated ability newborn by influencing community functional altering key serum. Also, life. Both optimized