Improved anticancer delivery of paclitaxel by albumin surface modification of PLGA nanoparticles

• DOI: 10.1186/s40199-015-0107-8
• Publication Date: 2015-04-22T08:32:11Z
• Authors: Mehdi Esfandyari-...; Seyed Hossein Mos...; Reza Faridi Majidi; Mona Noori Koopaei; Nazanin Shabani R...; Mohsen Amini; Behrad Darvishi; Seyed Nasser Ostad; Fatemeh Atyabi; Rassoul Dinarvand
• Keywords: PLGA; Zeta potential; Human serum albumin

Nanoparticles (NPs) play an important role in anticancer delivery systems. Surface modified NPs with hydrophilic polymers such as human serum albumin (HSA) have long half-life the blood circulation system.The method of nanoprecipitation was utilized for encapsulation paclitaxel (PTX) poly (lactic-co-glycolic acid) (PLGA). Para-maleimide benzoic hydrazide conjugated to PLGA surface modifications NPs, and then HSA attached on prepared by maleimide attachment thiol groups (cysteines) albumin. The application provides longer stealth due their escape from reticuloendothelial system (RES). Then physicochemical properties like morphology, size, zeta potential, in-vitro drug release were analyzed.The particle size ranged 170 190 nm increased about 20-30 after conjugation. potential -6 mV it decreased further conjugation proved Fourier transform infrared (FT-IR) spectroscopy, faster degradation Differential scanning calorimetry (DSC) characterization, other evidences increasing decreasing potential. PTX released a biphasic mode all colloidal suspensions. A sustained profile approximately 33 days detected burst effect loaded drug. vitro cytotoxicity evaluation also indicated that are more cytotoxic than plain NPs.HSA decoration may be suitable NPs.