Prediction of lisinopril pediatric dose from the reference adult dose by employing a physiologically based pharmacokinetic model

• DOI: 10.1186/s40360-020-00429-y
• Publication Date: 2020-07-29T08:07:53Z
• Authors: Memoona Rashid; Muhammad Sarfraz; Mosab Arafat; Amjad Hussain; Nasir Abbas; Muhammad Waqas Sadiq; Muhammad Fawad Ra...; Nadeem Irfan Bukhari
• Keywords: Lisinopril; Toddler; Body surface area

Abstract Background This study aimed to assess the pediatric lisinopril doses using an adult physiological based pharmacokinetic (PBPK) model. As empirical rules of dose calculation cannot calculate gender-specific and ignores age-related differences. Methods A PBPK model for healthy population was developed oral (fed fasting) IV administration PK-Sim MoBI® scaled down a virtual prediction in neonates infants, infants toddler, children at pre-school age, school age adolescents. The parameters were predicted above groups decremental 20 mg, 10 5 2.5 1.5 mg order accomplish producing parameters, similar (or comparable) that population. simulated compared computed conventional four methods, such as Young’s rule, Clark’s weight-based body surface area-based equations reported different studies. Results Though all subpopulations comparable those calculated by yet methods overestimated when respective PBPK-predicted doses. findings previous real time studies patients supported present dose. Conclusion Thus, seems have predictability potential since it takes into consideration changes related gender.