Associations of FoxP3 gene polymorphisms with severe recurrent respiratory papillomatosis in Korean patients

• DOI: 10.1186/s40463-017-0197-z
• Publication Date: 2017-03-15T12:05:21Z
• Authors: Tack-Kyun Kwon; Eun Jae Chung; Nuri Lee; Eun Youn Roh; Eun Young Song
• Keywords: Recurrent Respiratory Papillomatosis

FoxP3 is the most dependable marker for regulatory T cells which play a major role in immune tolerance. Foxp3 gene polymorphisms were associated with various autoimmune diseases and clearance of viral infections. We studied association severe RRP patients.A total 30 Korean patients 195 healthy controls enrolled. (rs5902434 del/ATT, rs3761548 C/A, rs3761549 C/T, rs2232365 G/A) determined by PCR sequencing.Genotype frequencies (GF) rs5902434 ATT/ATT GG significantly decreased female than (0.0% vs 23.0%, p = 0.039, OR 9.4 both).We showed that polymorphism could be an important protective factor susceptibility Koreans. Further studies on larger number other ethnic groups are needed to clarify association.