Role of LncRNA score and PVT1 in primary hyperparathyroidism-- a preliminary study

• DOI: 10.1186/s40463-021-00509-x
• Publication Date: 2021-04-28T16:09:35Z
• Authors: Dongxue Zhang; Bojun Wei; Long Li; Tao Jiang; Xiaoai Yao; Xin Liu; Yuyan Sun
• Keywords: PVT1

Background Dysregulated lncRNA score and PVT1 expression may be involved in cancer. However, relationships of lncRNAs with hyperparathyroidism parathyroid cancer (PC) diagnosis remain mysterious. Methods Using quantitative real-time polymerase chain reaction (RT-qPCR), profile was evaluated 57 patients primary hyperparathyroidism, including 11 46 adenoma (PA). Results Higher levels were associated increased serum calcium level after water ingestion PC risk ( P < 0.05). Accordingly, varying degrees hypercalcemia PC. A higher (but not PVT1) an independent factor PC, AUC up to 0.872 (95% CI: 0.756–0.945, 0.001). Moreover, more valuable (with 0.974, sensitivity 85.71% specificity 100%, respectively) than intact hormone (iPTH) predicting among (especially based on greater AUC, = 0.010). Conclusion Increased is correlated elevated calcium, which serve as a potential biomarker for diagnosis, especially hypercalcemia. Graphical Abstract