Molecularly imprinted polymers as solid-phase and dispersive solid-phase extraction sorbents in the extraction of antiretroviral drugs in water: adsorption, selectivity and reusability studies

• DOI: 10.1186/s40543-024-00418-4
• Publication Date: 2024-03-18T12:02:06Z
• Authors: Thabiso Xolo; Precious Mahlambi
• Keywords: Solid phase extraction; Molecularly imprinted polymer; Reusability

Abstract The antiretroviral drugs (ARVDs) have been reported to be among the emerging water pollutants as a results attention is being paid on their analysis. This work therefore explored for first time multi-template MIP selective removal of selected ARVDs (abacavir, efavirenz and nevirapine) in wastewater, river tap water. adsorption studies were conducted by determining effect an increase concentration solution contact between sorbent ARVDs. High efficiencies observed abacavir, nevirapine analytes within 5 min maximum efficiency was at 60 ranging from 94.76 96.93%. Adsorption kinetics showed that pseudo-second rate order best fitting model, while isotherms indicated Freundlich isotherm ( R 2 = 0.94–0.98) described mechanism onto MIPs. These electrostatic attractions influenced multilayer coverage chemisorption process. Selectivity presence competitors gave recoveries 92 98% target analytes, they 63–79% indicating good selectivity strong affinity polymer towards analytes. Reusability can reused up 8 cycles with above 92% all application MIP-DSPE method samples concentrations 28.75–178.02, 1.95–13.15 2.17–6.27 µg L −1 , respectively. indicate potential unplanned consumption upon drinking contaminated which could result resistance human body. Therefore, continuous monitoring well investigation strategies paramount importance.