MMP-3 in the peripheral serum as a biomarker of knee osteoarthritis, 40 years after open total knee meniscectomy

• DOI: 10.1186/s40634-018-0132-x
• Publication Date: 2018-06-15T07:27:29Z
• Authors: Ioannis Pengas; Suzanne Eldridge; Aggelos Assiotis; Michael McNicholas; Joao Espregueira ...; Lior Laver
• Keywords: Meniscus

To explore potential biomarkers in a meniscectomy-induced knee osteoarthritis model, at forty years after meniscectomy.We carried out forty-year study of 53 patients who, as adolescents, underwent open total meniscectomy and assessed two synovial serum biomarkers, namely glycosaminoglycan (GAG) matrix metalloproteinase-3 (MMP-3). Of the 30 available for review, 8 had contralateral operations were excluded. remaining 22 patients, 17 successful operated fluid aspirations also control aspirations. GAG MMP3 levels peripheral was measured using Alcian blue precipitation ELISA quantification, respectively. Patients their radiographs radiographic classified per Kellgren-Lawrence Ahlbӓck systems.At meniscectomy, MMP-3 remain increased (p = 0.0132) while reduced 0.0487) when compared to controls these correlate inversely. Furthermore, significantly correlated 0.0032, r 0.7734; p 0.0256, 0.5552) inversely 0.0308, - 0.6220; 0.0135, 0.6024), respectively, with both radiological scoring systems. Interestingly, we found that only not non-operated joint 0.0252, 0.7706 vs. 0.0764, 0.6576). Multiple regression analysis patient's quality life based on revealed an almost perfect result R2 0.9998 value 0.0087.Our results suggest could be used biomarker osteoarthritis, simple blood test. Larger cohorts are desirable order prove or disprove this finding.