Performance evaluation of Cerenkov luminescence imaging: a comparison of 68Ga with 18F

• DOI: 10.1186/s40658-019-0255-x
• Publication Date: 2019-10-25T17:13:10Z
• Authors: J. olde Heuvel; B. J. de Wit-van ...; K. N. Vyas; D. S. Tuch; M. R. Grootendorst; M. P. M. Stokkel; C. H. Slump
• Keywords: Medical physics. Medical radiology. Nuclear medicine; 03 medical and health sciences; 0302 clinical medicine; SDG 3 - Good Health and Well-being; Cerenkov luminescence imaging; Performance evaluation; R895-920; Intraoperative imaging; Ga-68 PSMA; Original Research

Abstract Background Cerenkov Luminescence Imaging (CLI) is an emerging technology for intraoperative margin assessment. Previous research only evaluated radionuclide 18-Fluorine ( 18 F); however, future applications in prostate cancer, 68-Gallium 68 Ga) seems more suitable, given its higher positron energy. Theoretical calculations predict that Ga should offer a signal-to-noise ratio than F; this the first experimental confirmation. The aim of study to investigate technical performance CLI by comparing F. Results linearity system, detection limit, spatial resolution, and uniformity were determined with LightPath imaging system. All experiments conducted clinically relevant activity levels vitro, using dedicated phantoms. For both radionuclides, linear relationship between concentration detected light yield was observed R 2 = 0.99). showed approximately 22 times detectable signal compared after 120 s exposure time × binning F 23.7 kBq/mL 1.2 Ga. resolution 1.31 mm 1.40 coefficient variance phantom 0.07 central field view. Conclusion superior over terms minimal limit. However, as could be expected, 0.1 less Given clinical constraints acquisition < mm, assessment feasible.