Precision dosimetry in yttrium-90 radioembolization through CT imaging of radiopaque microspheres in a rabbit liver model

• DOI: 10.1186/s40658-022-00447-1
• Publication Date: 2022-03-21T11:03:30Z
• Authors: E. Courtney Henry; Matthew Strugari; George Mawko; Kimberly Brewer; David Liu; Andrew C. Gordon; Jeffrey N. Bryan; Charles Maitz; James J. Karnia; Robert Abraham; S. Cheenu Kappadath; Alasdair Syme
• Keywords: Hounsfield scale; Bolus (digestion)

To perform precision dosimetry in yttrium-90 radioembolization through CT imaging of radiopaque microspheres a rabbit liver model and to compare extracted dose metrics those produced from conventional PET-based dosimetry.A calibration phantom was designed containing posts with nominal microsphere concentrations 0.5 mg/mL, 5.0 25.0 mg/mL. The mean Hounsfield unit the post volumes generate curve relate units concentration. A bolus 40 mg administered livers eight rabbits, followed by PET/CT imaging. CT-based activity distribution calculated application volume. Post-treatment performed convolution dose-voxel kernels PET- cumulated distributions. distributions compared linear regression, ANOVA, Bland-Altman analysis.A least-squares fit average concentration data confirmed strong correlation (r2 > 0.999) slope 14.13 HU/mg/mL. poor found between derived PET = 0.374), while ANOVA analysis revealed statistically significant differences (p < 10-12) MIRD-derived CT-derived dose. predicted an offset 15.0 Gy PET. within shown be more heterogeneous than coefficient variation equal 1.99 1.02, respectively.The benefits approach post-treatment include improved visualization distribution, reduced partial volume effects, better representation heterogeneity, mitigation respiratory motion effects. provides means extract accurate used refine understanding dose-response relationship, which could ultimately improve future patient outcomes.