Invasive solid papillary carcinoma with neuroendocrine differentiation of the breast: a case report and literature review

• DOI: 10.1186/s40792-020-00905-x
• Publication Date: 2020-06-19T11:03:52Z
• Authors: Xue Lin; Yoshiaki Matsumoto; Tomomi Nakakimura; Kazuo Ono; Shigeaki Umeoka; Masae Torii; Hiroshi Yoshibayashi; Masakazu Toi
• Keywords: Neuroendocrine differentiation; Neuroendocrine carcinoma

Solid papillary carcinoma (SPC) of the breast is a rare cancer that accounts for less than 1% all cancers. The optimal clinical management SPC remains controversial. Here, we report case invasive with neuroendocrine differentiation in addition to review current literature.A premenopausal 46-year-old female presented mass her left tended increase size over 10-month period. Mammography and ultrasonography revealed upper-inner quadrant. resulting images suggested category 3 tumor according Breast Imaging Reporting Data System (BI-RADS). A core needle biopsy (CNB) was performed, pathological findings showed solid pattern atypical cells suggestive noninvasive SPC. After partial mastectomy sentinel lymph node (SLNB), specimens were sent histopathological analysis further investigation. Postoperative Whole-breast radiation therapy adjuvant hormonal performed as postoperative treatments. Three years after surgery, multiple lung metastases detected, patient treated gonadotropin-releasing hormone agonist an aromatase inhibitor. Five months later, liver bone appeared, oral 5-fluorouracil chosen subsequent treatment. has been 5 date, she continuing take alive without any disease progression.We metastases. Further study needed clarify molecular characteristics behaviors explore treatment strategy.