Preoperative neutrophil-to-lymphocyte ratio plus platelet-to-lymphocyte ratio in predicting survival for patients with stage I–II gastric cancer

• DOI: 10.1186/s40880-016-0122-2
• Publication Date: 2016-06-25T19:00:52Z
• Authors: Xiaowei Sun; Xuechao Liu; Jianjun Liu; Shangxiang Chen; Dazhi Xu; Wei Li; Youqing Zhan; Yuanfang Li; Yingbo Chen; Zhiwei Zhou
• Keywords: Adult; Male; 0301 basic medicine; Neutrophils; Young Adult; 03 medical and health sciences; Stomach Neoplasms; Humans; Lymphocyte Count; Neutrophil-to-lymphocyte ratio; RC254-282; Aged; Aged, 80 and over; Inflammation; Platelet Count; Neoplasms. Tumors. Oncology. Including cancer and carcinogens; Middle Aged; Platelet-to-lymphocyte ratio; Prognosis; 3. Good health; Survival Rate; Treatment Outcome; Preoperative Period; Original Article; Female; Gastric cancer; Follow-Up Studies

The preoperative neutrophil-to-lymphocyte ratio (NLR) and the platelet-to-lymphocyte (PLR) are associated with poor prognosis of gastric cancer. We aimed to determine whether combination NLR PLR (NLR–PLR) could better predict survival patients after curative resection for stage I–II collected data from medical records cancer undergoing between December 2000 November 2012 at Sun Yat-sen Cancer Center. NLR–PLR was calculated as follows: both elevated (≥2.1) (≥120) were given a score 2, only one or neither 1 0, respectively. Kaplan–Meier analysis log-rank tests revealed significant differences in overall (OS) among scores 2 (P < 0.001). Multivariate showed that OS independently [hazard (HR) = 1.51, 95% confidence interval (CI) 1.02–2.24, P 0.039] TNM (HR 1.36, CI 1.01–1.83, 0.041). However, other systemic inflammation-based prognostic scores, including modified Glasgow score, nutritional index, platelet count NLR, not. In stage-stratified analysis, significance maintained I 0.001) II cancers 0.022). addition, area under receiver operating characteristic curve higher than those NLR-PLR is useful predictor postoperative may help identify high-risk rational therapy timely follow-up.