Successful recording of direct cortical motor-evoked potential from a pediatric patient under remimazolam anesthesia: a case report

• DOI: 10.1186/s40981-022-00555-y
• Publication Date: 2022-08-22T01:02:32Z
• Authors: Kotoe Kamata; Suguru Asagi; Yoshiteru Shimoda; Masayuki Kanamori; Nozomu Abe; Shigekazu Sugino; Teiji Tominaga; Masanori Yamauchi
• Keywords: Pediatric; Direct cortical motor-evoked potential; RC86-88.9; Medical emergencies. Critical care. Intensive care. First aid; Case Report; 3. Good health; 03 medical and health sciences; 0302 clinical medicine; Anesthesiology; Anesthesia; RD78.3-87.3; Remimazolam

Abstract Background Intraoperative motor-evoked potential (MEP) monitoring reduces postoperative motor deficits. Propofol-based total intravenous anesthesia is the gold standard for intraoperative myogenic MEPs. Although there is no contraindication to administering propofol in adults with peanut, soy, or egg allergies, its safety in children with these allergies remains unclear.

Case presentation A 12-year-old girl required general anesthesia under intraoperative direct cortical MEP (dc-MEP) monitoring due to supratentorial glioma. Remimazolam-based anesthesia was selected, instead of propofol, due to the patient’s egg hypersensitivity. Stable myogenic MEPs were recorded throughout the surgery with remimazolam at 0.9 mg/kg/h and remifentanil at 0.35 μg/kg/min, following adjustments of stimulation intensity and titration of remimazolam infusion. Neither intraoperative memory nor motor deficits were present after surgery.

Conclusions We present a pediatric case whose dc-MEP was recorded under remimazolam anesthesia. The cardiovascular stability and avoidance of propofol infusion syndrome with remimazolam were superior to propofol.