Perceptions of first-degree relatives of patients with rheumatoid arthritis about lifestyle modifications and pharmacological interventions to reduce the risk of rheumatoid arthritis development: a qualitative interview study

• DOI: 10.1186/s41927-018-0038-3
• Publication Date: 2018-10-03T11:21:12Z
• Authors: Gwenda Simons; Rebecca J Stack; Michaela Stoffer-...; Matthias Englbrecht; Erika Mosor; Christopher D Buc...; Kanta Kumar; Mats Hansson; Axel Hueber; Tanja Stamm; Marie Falahee; Karim Raza
• Keywords: Thematic Analysis; Risk Perception

There is increasing interest in the identification of people at risk rheumatoid arthritis (RA) to monitor emergence early symptoms (and thus allow therapy), offer lifestyle advice reduce impact environmental factors and potentially preventive pharmacological treatment for those high risk. Close biological relatives with RA are an increased developing therefore potential candidates research studies, screening initiatives interventions. To ensure success approaches this kind, a greater understanding perceptions group relating measures needed.Twenty-four first-degree patients existing diagnosis from UK, three Germany seven Austria (age: 21-67 years) took part semi-structured interviews exploring their risk, medicine changes Interviews were audio-recorded, transcribed verbatim analysed using thematic analysis.Many indicated that they anticipated being happy make such as losing weight or changing diet modify RA. Participants further order any it would be useful know personal Others implied not contemplate making changes, including stopping smoking, unless significantly eliminate Many had more negative about taking medication RA, listed concerns side effects one reasons wanting take medicines. willing consider drug interventions although some wish wait until developed.Information targeted considered should contain information extent which can quantified individual level how levels may differ depending on whether present. The benefits risks) clearly described.