The effect of octenidine dihydrochloride on the antibacterial activity of a formulated resin composite: an in vitro study

• DOI: 10.1186/s42269-024-01201-6
• Publication Date: 2024-04-28T23:02:02Z
• Authors: Mahitab Mansour; Tarek Salah; Haidy N. Salem
• Keywords: 03 medical and health sciences; Octenidine dihydrochloride; 0302 clinical medicine; Science; Q; Composite; Antibacterial and agar diffusion test

Abstract Background It has been noticed that failure of composite resin restorations can be attributed to either the two following causes: fracture or secondary caries. For reason, it is mandatory formulate a restorative material with antibacterial effect. An octenidine dihydrochloride (OCT) assessed as an alternative antimicrobial material, such chlorhexidine due their higher microbicidal effect and less cytotoxicity. Objective Current study aimed add different concentrations into experimental flowable evaluate its activity over periods time provide manufacturers more precise information. Methods A mix was formulated. Octenidine then added separately formulated at 1% wt. 1.5% concentration, respectively. Antibacterial against Streptococcus mutans using agar diffusion test compared commercial composite. Results showed by increasing percentage incorporated (1% 1.5%), respectively, efficacy increased. this also had significant decrease in Conclusions concluded incorporation Time OCT.