Murine liver-resident group 1 innate lymphoid cells regulate optimal priming of anti-viral CD8+ T cells

• DOI: 10.1189/jlb.3a0516-225r
• Publication Date: 2016-08-05T03:24:05Z
• Authors: Peter D Krueger; Sowmya Narayanan; Fionna A Surette; Michael G Brown; Sun-Sang J Sung; Young S Hahn
• Keywords: Innate lymphoid cell; CD49b; Priming (agriculture)

Abstract The liver contains 2 transcriptionally distinct group 1 ILC subsets: CD49a+ ILC1s and CD49b+ NK cells. However, little is known about how ILCs contribute to hepatic immune responses. Therefore, we characterized murine liver-resident found that express high levels of the inhibitory receptor NKG2A localize near DCs in perivascular spaces surrounding portal triads. Upon viral infection, signaling ILCs, especially ILC1s, inhibits CXCL9 expression required for robust accumulation IFN-γ+CD49b+ As a consequence, NKG2A−/− mice showed increased numbers IFN-γ-producing cells preferentially activate CD103+ DCs, leading sustained proliferation adoptively transferred, virus-specific CD8+ T Collectively, these data suggest play role maintaining as tolerogenic site by limiting recruitment peripheral during early phase infection. Furthermore, our findings implicate inhibition on may be novel vaccine strategy induce cell responses against persistent pathogens.