Clinical outcomes of on-pump coronary bypass using heparin-bonded circuits and reduced anti-coagulation compare favorably with off-pump approach

• DOI: 10.1191/0267659102pf541oa
• Publication Date: 2002-10-11T20:07:41Z
• Authors: Paul J O’Gara; Vijay Natarajan; Kevin Lilly; Ali Husain; Oz M Shapira; Richard J Shemin
• Keywords: Male; Heparin; Anticoagulants; Middle Aged; 3. Good health; Perfusion; 03 medical and health sciences; Treatment Outcome; 0302 clinical medicine; Coated Materials, Biocompatible; Humans; Female; Hospital Mortality; Coronary Artery Bypass; Aged; Retrospective Studies

Coronary artery bypass grafting (CABG) without cardio-pulmonary bypass (CPB), or off pump, has gained popularity by avoiding the postoperative morbidity related to the use of CPB. Previously, we have demonstrated that CABG done on pump using heparin-bonded cardiopulmonary bypass circuits (HBC) with a lower anti-coagulation protocol (LAP) attenuates these effects, reduces homologous blood product requirement, and improves clinical outcome when compared with conventional CPB circuits. Our purpose in this study was to compare off-pump CABG clinical outcomes to on-pump CABG using HBC with LAP. We retrospectively analysed preoperative and postoperative variables of all primary CABG ( n= 1214) performed at this institution from 1 January 1997 to 28 July 2000. These patients were divided into the on-pump ( n= 1152) and off-pump groups ( n= 62). HBC with LAP were used in all on-pump CABG cases. There was no statistical difference in preoperative comorbid risk factors except percentage of females (on pump, 30% vs. off pump, 44%; p= 0.02) and body surface area (on pump, 1.94± 0.25 ml vs. off pump, 1.85± 0.22 ml; p= 0.02). There was no difference in intraoperative and postoperative complications, risk-adjusted mortality, total blood product usage, or length of stay. The mean number of distal anastomoses performed was significantly different (on pump, 3.5± 0.82 vs. off pump 1.8± 0.82; p < 0.001). Despite similar preoperative risk factors, clinical outcomes and homologous blood requirements were not statistically different between the off-pump and on-pump groups. These endpoints should not be the only criteria to justify performing off-pump CABG.